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KMID : 0376219870240020281
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Chonnam Medical Journal
1987 Volume.24 No. 2 p.281 ~ p.290
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Inhibitory Effect of Clonidine on Salivary Secretion of Submaxillary Gland in Cats
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Abstract
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The inhibitory effect of clonidine on submaxillary salivation was investigated in ketamine-anesthetized cats.
1) Intravenous administration of clonidine (2.5-40μg/kg) reduced both sali￢vary secretion evoked by stimulation of chorda tympani and reflex salivation evoked by central end stimulation of lingual nerve, in a dose-dependent manner. The inhibitory effect of clonidine was prominent on the reflex salivation.
2) Intraventricular clonidine (10 μg/kg) produced a marked reduction of reflex salivation, and this effect was not affected by reserpine pretreatment. Prazo￢sin (50μg/kg, i. c. v.) showed a slight tendency of antagonism against clonidine, whereas yohimbine (l00μg/kg, i c. v.) inhibited the clonidine effect.
3) Inhibitory effect of clonidine on salivary secretion evoked by chorda stimulation was not affected by prazosin (0.2mg/kg, i. v) . whereas it was antagonized by yohimbine (0.5 mg/kg, i.v.).
4) Clonidine did not reduce the pilocarpine-induced salivation but slightly enhanced it.
5) Submaxillary vasodilatation evoked by chorda stimulation in atropinized cat was reduced by clonidine (20 μg/kg, i.v.).
These results suggest that the both central mechanism of activating the postsynaptic a2-adrenoceptors and peripheral mechanism of activating presy￢naptic a2-adrenoceptors which inhibit cholinergic transmission are involved in. the inhibitory effect of clonidine on submaxillary salivation.
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